Fatigue and Nausea
Malnutrition is a usual symptom of cirrhosis patients with NAFLD because the liver dysfunctions impair the body’s ability to absorb and use the nutrients. Patients may also report nausea, vomiting, and significant weight loss. Muscle cramps, weakness, nausea, and vomiting are calcium and magnesium deficiency symptoms due to malabsorption. Chronic nausea results from metabolic and digestive changes and a decreased ability to process and eliminate pollutants.
In addition, the most common symptom of liver diseases such as NAFLD is fatigue. Because of its particular role in regulating the storage, release, and creation of substrate for energy generation, the liver is a crucial player in the pathophysiology of fatigue. It responds delicately to the feedback that regulates the intake and release of these energy-generating substrates. Fatigue may be traced back to metabolic factors starting with substrate absorption from the gut, continuing via the portal passageways to glycogen storage, and finally being released to target organs. The inflammation of the hepatic tissues can also cause fatigue.
Fatigue can be distinguished as either central or peripheral fatigue. A lack of drive to engage in any mental or physical activity is a symptom of central fatigue. Typically, neuromuscular dysfunction and muscle weakness are symptoms of peripheral fatigue.
