Weight Gain and Unexplained Weight Loss
The liver communicates directly with the brain to control appetite and weight, which is crucial in regulating energy levels. The brain and liver engage in a two-way communication to regulate glucose production, achieved through the hypothalamus’s responsiveness to glucose, fatty acids, and vagal nerve activity.
Independent of bodyweight fluctuation, researchers observed that total weight changes were linked to a seven percent increased risk of incident NAFLD.
Consuming an unhealthy amount of calories and fructose have a role in developing NAFLD in patients. Moreover, an alanine aminotransferase ALT level of over 19 in women or 30 in men can also be an indicator of NAFLD risks if accompanied by other symptoms such as ascites, jaundice, and skin problems.
The abdominal swelling caused by ascites in NAFLD patients can also cause weight gain because of fluid retention. Edema in other body parts, such as hands and feet, can also add to the weight. In fact, there is a direct correlation between the amount of weight one loses and the improvement in liver histology. The liver’s enzymes, fat content, and histology will all improve as a bonus.
On the contrary, NAFLD patients may experience unexplained weight loss and a lack of appetite during the cirrhotic stage.
