Multiple Myeloma
An individual’s anion gap can be affected by many things, including diet, medications, and underlying medical conditions. For example, one medical condition that can cause a low anion gap is multiple myeloma.
Multiple myeloma is a type of cancer affecting plasma cells, a type of white blood cell. Plasma cells are responsible for producing antibodies, and when they become malignant, they have abnormal antibodies called M proteins. These M proteins can build up in the blood and cause problems with kidney function.
Additionally, M proteins can bind to other substances in the blood, such as calcium and immunoglobulins, which can also lead to kidney problems. As kidney function declines, so does the body’s ability to eliminate acids, resulting in metabolic acidosis and a low anion gap.
The good news is that treatments for multiple myeloma have come a long way in recent years, and patients with this condition can now enjoy long-term remission. For individuals who have been diagnosed with multiple myeloma or are experiencing symptoms that could be related to this condition, be sure to speak with a doctor about the best treatment options.
