Irregular Heart Rate
An erratic heartbeat is referred to as a cardiac arrhythmia. An irregular heartbeat, also known as an arrhythmia, can develop when the electrical signals that generally coordinate the heart’s beating become disrupted. The malfunctioning signaling leads the heart to beat abnormally quickly (tachycardia), slowly (bradycardia), or irregularly. Arrhythmias of the heart might feel like a fluttering or racing heart, but in most cases, they are entirely safe.
Histamines have arrhythmogenic properties and can increase automaticity and promote triggering activity when delivered locally, culminating in severe tachyarrhythmias. Their primary arrhythmogenic effects include increased sinus rate, ventricular automaticity, and a slowdown of atrioventricular conduction. Mast cells are plentiful in the human heart because it is both a source and a target of chemical mediators generated during allergic responses. When these cells recognize an allergen, they circulate histamine and other substances. In the absence of the enzyme that degrades histamine, the concentration of this molecule increases, resulting in intolerance. Histamine receptors are directly activated in the presence of an allergen, resulting in ventricular arrhythmias in worst-case scenarios.
