Crigler-Najjar Syndrome
The Crigler-Najjar syndrome is a highly uncommon genetic condition brought on by abnormally high levels of poisonous bilirubin in the blood. This uncommon genetic disorder is characterized by an inability to convert and remove bilirubin adequately. This condition runs in families. This problem is a genetic sickness; thus, it can strike anyone at anytime. If both parents contribute a copy of the autosomal recessive UGT1A1 mutant gene, this condition can be passed down to offspring during conception. However, if only one mutated gene were handed on to the offspring, the condition known as Gilbert syndrome would manifest itself, albeit in a milder form.
The Crigler-Najjar syndrome can be recognized by an excessive amount of unconjugated bilirubin in the blood. Crigler-Najjar syndrome can be further subdivided into two distinct forms. Kernicterus type 1 (CN1) is a severe disease that can be deadly in children. However, people with this disease may survive longer if they receive adequate treatment. Type 2 (CN2) is a more manageable strain than Type 1 (CN1). People who carry the CN2 mutation have a lower risk of developing kernicterus, and most of those born with the condition survive to adulthood.
