Phosphodiesterase-5 Inhibitors
Phosphodiesterase-5 inhibitors (PDE5I) are effective for treating enlarged prostate and lower urinary tract symptoms due to their ability to relax smooth muscle fibers in the bladder and prostate. This medication works by inhibiting the breakdown of cGMP, a substance that lowers blood pressure by regulating vascular tone and endothelial permeability. Ultimately, phosphodiesterase-5 inhibitors are responsible for the relaxation of smooth muscle cells, thus making it easier for men with an enlarged prostate to urinate.
In addition, phosphodiesterase-5 inhibitors effectively reduce the hyperactivity of the autonomic nervous system. As a result, the most common side effect of phosphodiesterase-5 inhibitors is headaches. Other less common side effects include flushing, dyspepsia, and nasal congestion.
This medication should be taken with caution in patients with cardiovascular disease and should not be used in patients with significant hepatic impairment. Phosphodiesterase-5 inhibitors can be taken orally or injected into the muscle. The recommended dose of phosphodiesterase-5 inhibitors for the treatment of enlarged prostate is 5 mg daily. In most cases, they are well tolerated and have few side effects. Phosphodiesterase-5 inhibitors offer a safe and effective treatment option for men with enlarged prostates.
