12 Enlarged Prostate Causes You Should Know (Common Triggers)

Diabetes

Evidence suggests that diabetes significantly increases the risk of developing benign prostatic hyperplasia. In addition, older adults with diabetes are more likely to experience lower urinary tract symptoms. This is because these two medical conditions share a common pathogenic mechanism.  

According to various studies, the International Prostate Symptom Score (IPSS) value and prostate volume in diabetic patients are significantly higher than in non-diabetic patients with prostate gland enlargement. Furthermore, diabetic patients are two times more likely to develop benign prostatic hyperplasia. Similarly, individuals with elevated blood glucose are reported to have three times the risk of having benign prostatic hyperplasia. 

As diabetes has already been established as a causative factor of benign prostatic hyperplasia, it is imperative to manage blood glucose levels to alleviate the lower urinary tract symptoms. Therefore, men with benign prostatic hyperplasia and diabetes should be more mindful of controlling both conditions using the correct medical interventions. 

Additional studies also reveal that benign prostatic hyperplasia can also cause the development of type-1 diabetes mellitus. In addition, based on studies, almost 60% of men with an enlarged prostate develop insulin resistance due to androgen deprivation therapy. This intervention is known to manage the symptoms related to prostate gland enlargement.