Unexplained Weight Loss
Hepatomegaly or enlarged liver might cause unexplained weight loss, particularly in patients with liver cirrhosis. The liver is responsible for storing any surplus glucose or sugar in the form of glycogen, which is a chain of glucose molecules. Glycogen is then subsequently released to fulfill the energy needs of the body. The liver directly interacts with the brain to regulate hunger and body weight. This is true even if other pathways are also engaged.
Most hormones secreted from the stomach and intestines are crucial in controlling appetite and maintaining healthy body weight. Aside from that, evidence shows that the liver plays an essential role in maintaining energy homeostasis. Research conducted by Rossetti and colleagues has shown that the brain can communicate directly with the liver to control glucose synthesis. This is accomplished through hypothalamic nutrient sensitivity to glucose, fatty acids, and vagal nerve activities.
It is also difficult to successfully treat malnutrition as the disease advances. The illness might be progressive if you lose more than five percent of your usual weight in six to twelve months. Consult your physician if there is no clear explanation for the recent weight loss.
