Easy Bruising
The hormone thrombopoietin (TPO) plays a significant role in forming platelets. The liver, namely its parenchymal and sinusoidal endothelial cells, and the kidneys are the primary organs responsible for producing TPO. TPO is responsible for regulating the development of megakaryocytes into platelets and binding it to the c-mpl receptor.
Platelets are blood cells necessary for the process of blood clotting. It is responsible for starting the coagulation cascade when an injury to tissue or blood vessels occurs. Clotting factors are then brought to the injured spot in the required order, one after the other. Liver damage results in a reduction in the rate of platelet production or an end to the process altogether.
On the other hand, the liver is also responsible for producing the soluble protein known as fibrinogen, which forms a fibrous web to support blood clotting. If the liver is damaged, it will generate fewer proteins necessary, making the hepatomegaly patient have excessive bleeding and easy bruising. Because of this, bruises often arise, mainly if they are located on the abdomen, back, or face, and seem to form for no apparent cause.
